Functions of homologous DNA recombination
نویسنده
چکیده
Homologous DNA (or genetic) recombination plays important roles in heredity and evolution. A recent study has shown that a physical linkage established by recombination between two or more homologous DNA regions or molecules is essential for the precise disjunction of homologous chromosomes in meiosis and the recovery of collapsed DNA replication forks. These physical linkages in recombination may also be involved in the establishment of mitochondrial homoplasmy. A recent study has also challenged some notions that were regarded as dogmas, such as the role of Holliday intermediates in gene conversion and crossing over. The concept that homologous recombination is generally promoted by proteins of the RecA/Rad51 family has been challenged by the observations that homologous pairing is promoted in vitro by ATP-independent proteins encoded by recombination genes. T. Shibata
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